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Updated: May 3, 2026

Dynamic Continuous Blood Extraction from Rat Heart via Noninvasive Microdialysis Technique
Published on: September 13, 2022
Role of microdialysis in pharmacokinetics and pharmacodynamics: current status and future directions
Francine Johansson Azeredo1, Teresa Dalla Costa1, Hartmut Derendorf2
1Programa de Pós-Graduação em Ciências Farmacêuticas, UFRGS, Porto Alegre, Brazil.
Abstract:
Diagnostic and therapeutic decisions in medical practice are still generally based on blood concentrations of drugs and/or biomolecules despite the knowledge that biochemical events and pharmacological effects usually take place in tissue rather than in the bloodstream. Microdialysis is a semi-invasive technique that is able to measure concentrations of the free, active drug or endogenous compounds in almost all human tissues and organs. It is currently being used to monitor brain metabolic processes and quantify tissue biomarkers, and determine transdermal drug distribution and tissue pharmacokinetics, confirming its importance as a widely used sampling technique in clinical drug monitoring and drug development as well as therapy and disease follow-up, contributing to rationalizing drug dosing regimens and influencing the clinical decision-making process.
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