[Tumor markers in hepatoma, gallbladder-biliary tract and pancreas cancer]

Possibilities for the early diagnosis of hepatoma, gallbladder-biliary tract cancer and pancreas cancer became getting higher by using method of monoclonal antibody. AFP, gamma-GTP, hepatoma specific gamma-GTP, P-III-P, PIVKA-II and 5'-NPD-V are sensitive and useful markers for diagnosis of hepatoma, CA 19-9 and CEA for gallbladder-biliary tract cancer and pancreas cancer, and DUPAN-2 and POA for pancreas cancer. Screening of sera of the patients with these tumor markers combined with image diagnosis are necessary for early and accurate diagnosis of the cancers. Everlasting effort to get the more sensitive and specific tumor markers are necessary. And missile therapy binding anti-cancer drugs to monoclonal antibodies are expected.