Corneal biomechanical characteristics in children with diabetes mellitus
Pınar Nalcacioglu-Yuksekkaya1, Emine Sen, Semra Cetinkaya
1Department of Pediatric Opthalmology, Dr Sami Ulus Children's Health and Disease Training and Research Hospital, Babur Street No: 44, Altindag, Ankara, 06080, Turkey, drpinarnalcaci@yahoo.com.
Insights
Type 1 diabetes mellitus (DM) in children does not impact corneal biomechanical properties. This study found no significant differences in corneal hysteresis or resistance factor between children with and without type 1 DM.
Area of Science:
- Ophthalmology
- Endocrinology
- Biomedical Engineering
Background:
- Type 1 diabetes mellitus (DM) is a chronic metabolic disorder.
- Ocular health, particularly corneal biomechanics, may be affected by systemic diseases.
- Understanding these effects in children is crucial for long-term eye care.
Purpose of the Study:
- To compare corneal biomechanical properties in children with type 1 DM versus healthy children.
- To investigate the potential influence of type 1 DM on corneal hysteresis (CH) and corneal resistance factor (CRF).
Main Methods:
- A cross-sectional study involving 68 children with type 1 DM and 74 healthy controls.
- Corneal biomechanical parameters including CH, CRF, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were measured using the Ocular Response Analyzer (ORA).
Main Results:
- No statistically significant differences were observed between the type 1 DM group and the control group for CH (p=0.624), CRF (p=0.207), IOPg (p=0.263), or IOPcc (p=0.395).
- Mean CH values were 10.8 ± 1.5 mmHg (DM) vs. 10.7 ± 1.7 mmHg (Control).
- Mean CRF values were 10.9 ± 1.9 mmHg (DM) vs. 10.5 ± 1.6 mmHg (Control).
Conclusions:
- Type 1 diabetes mellitus in childhood does not appear to significantly alter corneal biomechanical properties.
- Corneal biomechanics remain largely unaffected by type 1 DM during childhood, suggesting resilience of corneal tissue.
Abstract:
To compare the corneal biomechanical properties in children with type 1 diabetes mellitus (DM) and healthy children. In this cross-sectional study, the study and control groups were composed of 68 children with DM and 74 healthy children, respectively. The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with the ocular response analyzer (ORA). Associations between ocular and diabetic parameters were also evaluated. There were no statistically significant differences between the two groups in age or gender distribution. The mean CH was 10.8 ± 1.5 and 10.7 ± 1.7 mmHg while the mean CRF was 10.9 ± 1.9 and 10.5 ± 1.6 mmHg in the diabetic group and control group, respectively. The mean IOPg was 15.9 ± 3.7 and 15.2 ± 3.4 mmHg, and the mean IOPcc was 15.8 ± 3.0 and 15.3 ± 3.4 mmHg in the diabetic and control group, respectively. There were no statistically significant differences between the two groups for CH, CRF, IOPg, and IOPcc measurements (independent t test, p = 0.624, p = 0.207, p = 0.263, p = 0.395, respectively). This study shows that type 1 DM does not have any effect on the corneal biomechanical parameters in childhood.
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