Related Experiment Video
Updated: May 3, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
The prodrug platin-A: simultaneous release of cisplatin and aspirin
Rakesh K Pathak1, Sean Marrache, Joshua H Choi
1NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602 (USA) http://shanta.chem.uga.edu.
Abstract:
Cancer-associated inflammation induces tumor progression to the metastatic stage, thus indicating that a chemo-anti-inflammatory strategy is of interest for the management of aggressive cancers. The platinum(IV) prodrug Platin-A was designed to release cisplatin and aspirin to ameliorate the nephrotoxicity and ototoxicity caused by cisplatin. Platin-A exhibited anticancer and anti-inflammatory properties which are better than a combination of cisplatin and aspirin. These findings highlight the advantages of combining anti-inflammatory treatment with chemotherapy when both the drugs are delivered in the form of a single prodrug.
More Related Videos
Related Concept Videos
Prodrugs
Prodrugs help overcome...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Oral Drug Delivery Systems: Delayed-Release Systems
Drug Metabolism: Phase II Reactions

