Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural Control of Dual Emission in Coumarin Fluorophores for Visualizing Protein Droplet Maturation.

Angewandte Chemie (International ed. in English)·2026
Same author

Cage-Type Porous Organic Salts as Ship-in-a-Bottle Nanoreactors for Light-Transparent and Reusable Molecular Photocatalysts.

Angewandte Chemie (International ed. in English)·2026
Same author

Development of Sub-50 nm Core-Shell Silica Nanoparticles With Controlled In Vivo Behavior for <sup>19</sup>F Magnetic Resonance Imaging.

Angewandte Chemie (International ed. in English)·2026
Same author

Kupffer Cell Capture-Evading Modifiable Sub-20 nm Lipid Nanodisc-Based <sup>19</sup>F Magnetic Resonance Imaging Probes.

Journal of the American Chemical Society·2026
Same author

Controlling Intramolecular Rotation with Five-Membered Heterocycles Facilitates the Design of Highly Cell-Permeable Xanthene-Based Fluorogenic Probes.

Journal of the American Chemical Society·2025
Same author

Live-Cell Monitoring and Omics Analysis of Liquid-Solid Transitions of Biomolecular Condensates.

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: May 3, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

12.3K

Ratiometric MRI sensors based on core-shell nanoparticles for quantitative pH imaging.

Satoshi Okada1, Shin Mizukami, Takao Sakata

  • 1Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Advanced Materials (Deerfield Beach, Fla.)
|January 24, 2014
PubMed
Summary

New ratiometric MRI sensors use paramagnetic cores and pH-sensitive shells to enable quantitative pH imaging. By measuring the r2 /r1 ratio, these sensors provide pH sensitivity for advanced medical diagnostics.

Keywords:
contrast agentscore-shell nanoparticlesmagnetic resonance imagingpH-responsive polymersratiometric sensors

More Related Videos

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

5.8K
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

9.7K

Related Experiment Videos

Last Updated: May 3, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

12.3K
Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

5.8K
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

9.7K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Magnetic Resonance Imaging

Background:

  • Ratiometric MRI sensors combine paramagnetic cores and pH-sensitive polymer shells.
  • This core-shell design allows for the integration of distinct NMR relaxation properties within a single nanoparticle.
  • Such sensors are crucial for developing advanced diagnostic tools.

Purpose of the Study:

  • To develop and characterize novel ratiometric MRI sensors for pH imaging.
  • To investigate the pH sensitivity of these sensors using longitudinal (r1) and transverse (r2) relaxivity.
  • To demonstrate the feasibility of quantitative pH imaging using the r2 /r1 ratio.

Main Methods:

  • Fabrication of core-shell nanoparticles with paramagnetic cores and pH-sensitive polymer shells.
  • Measurement of longitudinal (r1) and transverse (r2) relaxivity at varying pH levels.
  • Quantitative pH imaging using the r2 /r1 ratio on a clinical 3 T MRI scanner.

Main Results:

  • The ratiometric MRI sensors exhibited pH sensitivity in their transverse relaxivity (r2).
  • No significant pH sensitivity was observed in the longitudinal relaxivity (r1).
  • Quantitative pH imaging was successfully achieved by analyzing the r2 /r1 ratio.

Conclusions:

  • Ratiometric MRI sensors offer a viable platform for pH-dependent imaging.
  • The r2 /r1 ratio effectively captures pH variations, enabling quantitative measurements.
  • These sensors hold promise for in vivo pH monitoring and disease diagnosis.