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Related Concept Videos

Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

29
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
29
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

27
Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
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Related Experiment Video

Updated: May 3, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
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Aging effects on the resting state motor network and interlimb coordination.

Elena Solesio-Jofre1, Leen Serbruyns, Daniel G Woolley

  • 1Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, KU Leuven, Tervuurse Vest 101, 3001, Leuven, Belgium.

Human Brain Mapping
|January 24, 2014
PubMed
Summary

Aging increases motor network connectivity, potentially impairing bimanual coordination. This study links heightened resting-state functional connectivity in motor areas to poorer performance on visuomotor tasks in healthy adults.

Keywords:
agingbimanual coordinationfunctional connectivitylifespanmotor networkresting state

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Area of Science:

  • Neuroscience
  • Aging Research
  • Motor Control

Background:

  • Resting-state functional connectivity (rsFC) changes in the motor network during aging are variable.
  • The link between altered rsFC and age-related bimanual coordination deficits is not well understood.

Purpose of the Study:

  • To investigate age-related changes in motor network rsFC.
  • To determine the relationship between motor network rsFC and bimanual visuomotor task performance across the adult lifespan.

Main Methods:

  • Examined rsFC in 128 healthy participants (aged 18-80 years) using functional magnetic resonance imaging (fMRI).
  • Assessed performance on a novel bimanual visuomotor task.
  • Conducted a control analysis on the default mode network (DMN).

Main Results:

  • Found age-related increases in rsFC between interhemispheric dorsal and ventral premotor areas.
  • These increases in motor network connectivity correlated with poorer bimanual visuomotor task performance.
  • Control analysis confirmed motor system specificity of observed age-related rsFC increases.

Conclusions:

  • Increased rsFC within the aging motor network may indicate a loss of functional specialization.
  • This loss of specialization might occur in both active and resting brain states.
  • Findings suggest a neural mechanism for age-related decline in motor control.