Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.6K
Skin Cancer01:30

Skin Cancer

5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Pigmentation01:19

Pigmentation

3.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
3.8K
Management of Insomnia01:19

Management of Insomnia

785
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
785

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Night Terrors as Prodromal Symptom of Obstructive Sleep Apnoea-Induced Arrhythmia: A Case Report.

Respirology case reports·2026
Same author

Concurrent hepatic cirrhosis and chronic lymphocytic leukemia: a challenging coexistence: a case report.

Journal of medical case reports·2026
Same author

FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils.

Iranian journal of otorhinolaryngology·2026
Same author

Comparison of the effects of microlearning and webinars on knowledge and self-efficacy of emergency medical technicians (EMTs) in the diagnosis and treatment of cardiac arrhythmias.

BMC emergency medicine·2026
Same author

Automatic classification of uveal melanoma response patterns following ruthenium-106 plaque brachytherapy using ultrasound images and deep convolutional neural network.

Scientific reports·2025
Same author

Differential Complexity of Information Processing During Motor Imagination in Adults Versus Children.

Basic and clinical neuroscience·2025
Same journal

Testicular Torsion: Time to Care and Ethnicity.

Iranian journal of medical sciences·2026
Same journal

Human Urogenital Myiasis Caused by <i>Psychoda Albipennis</i> Larvae (Diptera: Psychodidae) in Sanandaj, Iran: A Case Report.

Iranian journal of medical sciences·2026
Same journal

Practical and Implementation Challenges of Three Important Psychometric Indices.

Iranian journal of medical sciences·2026
Same journal

Assessment of Lymph Node Invasion and Associated Risk Factors in Intermediate-Risk Prostate Cancer: A Retrospective Cross-Sectional Study.

Iranian journal of medical sciences·2026
Same journal

<i>In Vitro</i> Effect of Lithium Chloride on Adipose Tissue Derived Stem Cells Proliferation and Growth Kinetic.

Iranian journal of medical sciences·2026
Same journal

Indirect Costs of Non-Communicable Diseases within the Top Ten Causes of Mortality Worldwide: A Systematic Literature Review.

Iranian journal of medical sciences·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

17.8K

Urinary melatonin levels and skin malignancy.

Reza Ghaderi1, Samineh Sehatbakhsh2, Mehdi Bakhshaee2

  • 1Department of Dermatology, Birjand University of Medical Sciences, Birjand, Iran;

Iranian Journal of Medical Sciences
|January 24, 2014
PubMed
Summary
This summary is machine-generated.

Low melatonin levels, indicated by reduced 24-hour urinary 6-sulfatoxymelatonin, may increase skin cancer risk in humans. This study found significantly lower melatonin levels in skin cancer patients compared to healthy controls.

Keywords:
Basal cell carcinomaMelatoninSkin neoplasmSquamous cell carcinoma

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.4K

Related Experiment Videos

Last Updated: May 3, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

17.8K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.4K

Area of Science:

  • Oncology
  • Endocrinology
  • Dermatology

Background:

  • Melatonin is known to inhibit tumor development in various experimental models.
  • Light at night suppresses melatonin, potentially increasing cancer risk, including skin cancer.
  • Previous research on light-at-night effects on skin cancer was limited to animal studies.

Purpose of the Study:

  • To investigate the association between 24-hour urinary 6-sulfatoxymelatonin levels and the risk of developing skin cancer in humans.
  • To compare melatonin levels in individuals with skin cancer versus healthy controls.

Main Methods:

  • A case-control study involving 70 patients with skin cancer and 70 healthy controls.
  • Measurement of 24-hour urinary 6-sulfatoxymelatonin using the ELISA method.
  • Analysis of skin cancer types, including basal cell carcinoma and squamous cell carcinoma.

Main Results:

  • Mean 24-hour urinary 6-sulfatoxymelatonin levels were significantly higher in the healthy control group (P<0.001).
  • Skin cancer patients exhibited lower levels of 24-hour urinary 6-sulfatoxymelatonin.
  • Sleep duration differed significantly between the case and control groups (P=0.001).

Conclusions:

  • Lower 24-hour urinary 6-sulfatoxymelatonin levels appear to be associated with an increased susceptibility to skin cancer in humans.
  • Further research is warranted to confirm this association and elucidate the underlying mechanisms.