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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Related Experiment Video

Updated: May 3, 2026

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Ovarian Stem Cells-the Pros and Cons.

Ayelet Evron¹, Zeev Blumenfeld¹

¹8 Ha'Aliyah St., Reproductive Endocrinology Dept. OB/GYN, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.

Clinical Medicine Insights. Reproductive Health

|January 24, 2014

Summary

The debate on postnatal de novo oogenesis in mammals, including humans, questions the traditional view of a fixed egg supply. Emerging research suggests germ-line stem cells (GSCs) may replenish oocytes throughout reproductive life.

Keywords:

de novo oogenesis germline stem cells ovarian stem cells primordial follicle pool

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Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

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Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

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Last Updated: May 3, 2026

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

Published on: September 10, 2014

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

Area of Science:

Reproductive Science
Developmental Biology
Stem Cell Biology

Background:

Historically, mammalian females were believed to exhaust their oocyte supply at birth.
The traditional model posits a fixed prenatal ovarian follicle pool that diminishes with age.

Purpose of the Study:

To review recent evidence supporting postnatal de novo oogenesis in mammals and humans.
To present arguments from both proponents and opponents of this controversial concept.

Main Methods:

Review of contemporary research integrating stem cell biology and novel experimental techniques.
Analysis of studies investigating the potential for germ-line stem cells (GSCs) to produce oocytes postnatally.

Main Results:

Emerging evidence challenges the long-held belief of a finite oocyte pool.
Research suggests that germ-line stem cells (GSCs) may contribute to oocyte replenishment throughout a female's reproductive lifespan.

Conclusions:

The concept of postnatal de novo oogenesis is a revolutionary idea in reproductive biology.
Ongoing research and debate continue to shape our understanding of ovarian function and female fertility.