Blood clot simulation model by using the Bond-Graph technique

Area of Science:

• Biomedical Engineering
• Computational Fluid Dynamics
• Medical Device Simulation

Background:

• Cardiovascular diseases, including heart attacks and strokes, result in 17 million deaths yearly.
• Cerebral strokes are often caused by occluding blood clots, necessitating catheter-based removal.
• Mechanical thrombectomy devices are increasingly used for clot removal, requiring accurate simulation models.

Purpose of the Study:

• To determine and optimize a simulation model for blood clots.
• To integrate this model with existing mechanical thrombectomy device simulations.
• To provide a foundational model for future advancements in clot removal technology.

Main Methods:

• Utilized a multidomain technique to analyze clot-artery wall and platelet interactions.
• Derived mathematical equations to define the comprehensive blood clot model.
• Employed a consecutive approximation approach to refine the model and address challenges.

Main Results:

• Developed a simulation model that characterizes blood clot elasticity.
• The model accounts for the potential detachment process from the artery wall.
• Successfully outlined the behavior laws essential for future clot simulation models.

Conclusions:

• The presented blood clot model is suitable for integration into mechanical thrombectomy simulations.
• This research contributes to the advancement of minimally invasive stroke treatments.
• The established model provides a basis for enhanced understanding and simulation of clot behavior.