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Reducing agents decrease the oxidative burst and improve clinical outcomes in COPD patients: a randomised controlled
Marco Contoli1, Giulia Gnesini1, Giacomo Forini1
1Department of Medical Sciences, Research Centre on Asthma and COPD, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy.
Thescientificworldjournal
|January 24, 2014
Summary
Inhaling sulphurous thermal water reduced airway oxidant stress in COPD patients. This treatment also improved health status, as measured by the COPD Assessment Test (CAT) questionnaire, one month after treatment.
Area of Science:
- Pulmonary Medicine
- Respiratory Health
- Environmental Medicine
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is often associated with increased airway oxidant stress.
- Inhalation of thermal water, known for its antioxidant properties, is a traditional therapy for COPD.
Purpose of the Study:
- To investigate the impact of sulphurous thermal water, a source of reducing agents, on airway oxidative stress.
- To assess the effects of this therapy on clinical outcomes in patients with moderate-to-severe COPD.
Main Methods:
- A randomized trial involving 40 moderate-to-severe COPD patients.
- 12-day inhalation treatment with either sulphurous thermal water or isotonic saline.
- Assessment of superoxide anion production in exhaled breath condensate and clinical outcomes.
Main Results:
- Sulphurous thermal water inhalation significantly reduced superoxide anion production in exhaled breath condensate.
- A notable improvement in the COPD Assessment Test (CAT) scores was observed one month post-treatment in the sulphurous water group.
- No significant changes were noted in the saline group.
Conclusions:
- Inhalation of sulphurous thermal water demonstrates an in vivo antioxidant effect in COPD patients.
- This therapy led to an improved health status in COPD patients.
- Further research is needed to confirm long-term clinical outcome modifications.
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