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Updated: May 3, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Ethyl N-(3-cyano-1H-indol-2-yl)form-imidate
Yang Ruchun1, Zhang Hui1, Cao Banpeng1
1Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, People's Republic of China.
The study details the crystal structure of C12H11N3O, revealing an E-conformation imino bond. Molecules form chains through N-H⋯Ncyano hydrogen bonds in the crystal lattice.
Area of Science:
- Crystallography
- Organic Chemistry
- Supramolecular Chemistry
Background:
- Understanding molecular conformation and intermolecular interactions is crucial in crystal engineering.
- The specific compound C12H11N3O presents an interesting case for structural analysis.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C12H11N3O.
- To investigate the intermolecular interactions and their role in crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding networks and conformational preferences.
Main Results:
- The title compound, C12H11N3O, exhibits an imino bond with an E conformation.
- Adjacent molecules are interconnected via N-H⋯Ncyano hydrogen bonds, forming a characteristic chain structure along the [110] direction.
Conclusions:
- The crystal structure of C12H11N3O is characterized by specific conformational and hydrogen bonding patterns.
- These interactions dictate the supramolecular architecture, leading to the observed chain formation.
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