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Updated: May 3, 2026
Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines
Published on: August 1, 2012
Neolactoferrin as a stimulator of innate and adaptive immunity
A D Chernousov1, M F Nikonova2, N I Sharova2
1Institute of Immunology, Federal Medical and Biological Agency, Kashirskoe shosse, 24/2, Moscow, Russia, 115478 ; Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, Russia, 119334.
Abstract:
The effect of the innovative product Neolactoferrin, a natural combination of recombinant human lactoferrin (90%) and goat lactoferrin (10%) isolated from the milk of transgenic goats carrying the full-length human lactoferrin gene, on human immune system cells was studied. Neolactoferrin enhanced the production of IL-1β. Neolactoferrin saturated with iron ions increased the synthesis of pro-inflammatory cytokine TNFα. It determined the direction of the differentiation of precursor dendrite cells. Under the action of T cells, Neolactoferrin amplified the expression of the transcription factors responsible for the differentiation of Th- and Treg-cells and stimulated the production of both IFNγ and IL-4. The results suggest that Neolactoferrin exhibits an immunotropic activity and hinders the development of immune inflammatory processes. Iron saturation of Neolactoferrin increases its pro-inflammatory activity.
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