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Updated: May 3, 2026

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

Systemic heparinisation in laparoscopic live donor nephrectomy.

Charlotte Crotty¹, Yasmin Tabbakh¹, Sarah A Hosgood¹

¹Transplant Group, Department of Infection, Immunity and Inflammation, Leicester General Hospital, University of Leicester, Leicester LE5 4PW, UK.

Journal of Transplantation

|January 24, 2014

Summary

This summary is machine-generated.

Omitting systemic heparinisation during laparoscopic live donor nephrectomy (LDN) is safe and feasible. This approach does not negatively impact donor or recipient outcomes, including graft survival.

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Area of Science:

Nephrology
Surgical Innovation
Transplantation Immunology

Background:

Systemic heparinization is standard practice during laparoscopic live donor nephrectomy (LDN) to prevent renal vascular thrombosis.
The necessity and impact of heparin on outcomes in LDN remain subjects of investigation.

Purpose of the Study:

To compare the outcomes of laparoscopic live donor nephrectomy with and without systemic heparin administration.
To evaluate the safety and efficacy of omitting heparin in LDN.

Main Methods:

A retrospective analysis of 186 consecutive LDN patients (April 2008–November 2012).
Patients were divided into two groups: those who received systemic heparin (n=109) and those who did not (n=77).
Outcome measures included donor/recipient complications, initial graft function, and 12-month graft survival.

Main Results:

Demographics and warm ischemic times (WIT) were similar between heparinized and non-heparinized groups (WIT: 5 ± 3 minutes).
No significant differences were observed in complication rates, graft thrombosis, primary non-function, or 12-month graft survival.
Delayed graft function rates were comparable (3.6% vs. 1.2%, P=0.405).

Conclusions:

Omitting systemic heparinization in laparoscopic live donor nephrectomy is a safe and feasible strategy.
The absence of heparin does not compromise donor safety, recipient outcomes, or graft survival.