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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
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Thyroid metastasis from nonsmall cell lung cancer.
Tariq Namad1, Jiang Wang2, Ralph Shipley3
1Division of Hematology and Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Case Reports in Oncological Medicine
|January 24, 2014
Summary
Thyroid metastases from lung cancer are uncommon but require careful management. A multidisciplinary approach is crucial for determining the best treatment strategy, balancing surgery with systemic therapy or radiation.
Area of Science:
- Oncology
- Endocrinology
- Pulmonology
Background:
- Thyroid metastases are rare, accounting for less than 4% of thyroid malignancies.
- Lung cancer is an uncommon primary source for thyroid metastases.
Purpose of the Study:
- To evaluate the clinical presentations and therapeutic options for patients with lung cancer metastatic to the thyroid.
- To highlight the importance of accurate diagnosis and staging in managing thyroid metastases.
Main Methods:
- Case report of a patient with adenocarcinoma of the lung metastatic to the thyroid.
- Literature review of similar cases reported between 1997 and 2013 via PubMed search.
- Histopathological examination and TTF-1 staining for diagnosis.
- Positron Emission Tomography (PET) scan for staging.
Main Results:
- A 48-year-old female presented with diffuse goiter 9 months post-lung cancer treatment.
- Histopathology confirmed metastatic adenocarcinoma of lung origin in the thyroid with TTF-1 positivity.
- PET scan revealed additional mediastinal lymphadenopathy, indicating widespread disease.
Conclusions:
- Treatment for metastatic thyroid disease necessitates a multidisciplinary approach.
- Thyroidectomy may be considered for solitary metastases, but comprehensive staging is vital.
- Further metastatic workup guides decisions between systemic therapy and palliative radiation.
