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Updated: May 3, 2026

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Published on: October 14, 2016
Fluoride levels and osteosarcoma
Simmi Kharb1, Ravindra Sandhu1, Zile Singh Kundu2
1Department of Biochemistry, Pt.BDS PGIMS, Rohtak, India.
Context:
Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma.
Aims:
The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water.
Settings And Design:
The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls).
Materials And Methods:
Serum and drinking water fluoride levels were estimated by ion selective electrode.
Statistical Analysis Used:
The data were computed as mean ± SD and Student's t test was applied.
Results:
Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P > 0.05, P > 0.001, respectively).
Conclusions:
These results suggest a link between fluoride exposure and osteosarcoma.
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