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The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis
Published on: December 11, 2012
Activation of MAP kinase pathways in Galleria mellonella infected with Bacillus thuringiensis
Iwona Wojda1, Konrad Koperwas1, Teresa Jakubowicz1
1Department of Immunobiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Lublin, Poland.
Abstract:
We followed changes in the level of phospho-MAP kinases in the greater wax moth Galleria mellonella after infection with Bacillus thuringiensis. We observed an enhanced level of phosphorylated p38 and JNK in fat bodies of the infected larvae. In hemocytes, injection of B. thuringiensis caused the highest increase in phospho-JNK, however, all pathways were activated after aseptic injection. We report that Galleria mellonella larvae exposed to heat shock before infection showed an enhanced level of phosphorylated JNK in fat body. This finding is relevant in the light of our previous reports, which submit evidence that pre-shocked animals are more resistant to infection.
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