[Study on IEUBK model localization based on behavior parameters of children from southwestern China]

IEUBK (Integrated Exposure Uptake Biokinetic Model for Lead in Children) model was developed and recommended by the US Environmental Protection Agency. In order to apply IEUBK model to China, we firstly performed sensitivity analysis, which showed that simulated blood Pb (PbB) concentration was most sensitive to soil/dust exposure pathway. In-home surveys were conducted in Y province of China to gather information on children's behavior parameters and environmental samples for parameters localization. Finally the verified model was applied to predict children's PbB level in comparison with that modeled by default parameter values. Results showed that geometric mean values of children's PbB concentration were 5.28 microg x dL(-1), 5.77 microg x dL(-1), 6.03 microg x dL(-1) and 6.32 microg x dL(-1) before and 5, 10 and 20 years after the establishment of a new factory in the neighboring G province. The simulated PbB after 20 years was 61.39% lower by original model than that by the localized model.