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C-Reactive protein and soluble intracellular adhesion molecule-1 are related to pulse wave reflection in type 1

Anita Rogowicz-Frontczak1, Stanislaw Pilacinski, Aleksandra Araszkiewicz

  • 1Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.

Journal of Diabetes
|January 25, 2014
PubMed

Insights

Inflammation markers like hs-CRP and sICAM-1 are linked to arterial stiffness parameters in type 1 diabetes (T1D). This study highlights a connection between inflammation and cardiovascular risk indicators in T1D patients.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Immunology

Background:

  • Cardiovascular (CV) complications in diabetes are a significant concern, with inflammation's role debated.
  • Arterial stiffness and wave reflection are key contributors to CV complications.
  • Investigating the link between inflammation and wave reflection parameters in type 1 diabetes (T1D) is crucial.

Purpose of the Study:

  • To determine the correlation between inflammatory markers and pulse wave reflection parameters in T1D patients.
  • To assess if specific inflammatory markers are associated with arterial stiffness in T1D.

Main Methods:

  • 145 T1D patients were analyzed.
  • Serum levels of high-sensitivity C-reactive protein (hs-CRP), matrix metalloproteinase (MMP)-9, soluble intracellular adhesion molecule-1 (sICAM-1), and myeloperoxidase (MPO) were measured.
  • Pulse wave analysis was used to assess central (cAIx) and peripheral (pAIx) augmentation indices.

Main Results:

  • Multivariate regression analysis showed associations between cAIx/pAIx and hs-CRP.
  • Significant correlations were found between cAIx/pAIx and sICAM-1 levels.
  • These associations remained significant after adjusting for diabetes control, lipids, and microangiopathy.

Conclusions:

  • Wave reflection parameters are related to inflammatory markers in type 1 diabetes.
  • Inflammation may contribute to arterial stiffness and CV risk in T1D.
  • Further research is warranted to explore therapeutic interventions targeting inflammation.
Abstract

Keywords:
arterial stiffnessinflammationtype 1 diabeteswave reflection关键词：动脉僵硬度，炎症，1型糖尿病，波反射

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