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Two bioactive compounds from the Chinese scorpion Buthusmartensii Karsch
Jiayu Gao1, Weiping Yin, Ting Gao
1a School of Chemical Engineering and Pharmaceutics, Henan University of Science and Technology , Luoyang , Henan 471023 , P.R. China.
Abstract:
Two compounds, 3β-acetoxyl,2,14,22-trihydroxy,19-hydroxymethyl,9α,5β,14β-card-20(22)enolide (1) and 1,2,3,4-tetrahydro-6-hydroxy1-5-pyrimidinecarbox-aldehyde (2), were isolated from arthropods in scorpion, Buthus martensii Karsch, by medium pressure liquid chromatography with silica gel as stationary phase and RP-HPLC analysis technology. The structures were elucidated on the basis of NMR spectroscopic analysis and HR-ESI-MS determination. It was found that (1) is a novel compound and both compounds showed inhibitory activities against the Gram-positive bacteria Bacillus subtilis (minimum inhibitory concentrations = 15 μg/mL), with diameter of inhibition zone at ϕ = 6.0 mm (compound 1) and ϕ = 9.0 mm (compound 2), respectively.
