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Updated: May 3, 2026
A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Addicted to secrete - novel concepts and targets in cancer therapy
Nicolas Dejeans1, Serge Manié2, Claudio Hetz3
1Inserm U1053, F-33000 Bordeaux, France; University Bordeaux-Segalen, F-33000 Bordeaux, France.
Abstract:
The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic potential of targeting the UPR in cancer models. However, the UPR may not be the only druggable target of the SP. Moreover, recent studies have revealed other contributions of the SP to cancer development. This article does not intend to describe the well-established implication of UPR signaling pathways in cancer cell life and cell decision, but rather aims at defining the concept of 'tumor cell secretory addiction', from molecular, cellular, and therapeutic perspectives. Furthermore, the implication of UPR modulations in this context will be discussed.
Insights
This study introduces "tumor cell secretory addiction," a concept exploring the secretory pathway's role in cancer beyond the unfolded protein response (UPR). It highlights new therapeutic targets for cancer treatment.
Area of Science:
- Cell Biology
- Cancer Research
- Molecular Medicine
Background:
- The unfolded protein response (UPR) is crucial for secretory pathway (SP) adaptation.
- Targeting UPR shows therapeutic potential in cancer, but other SP aspects are also druggable.
- The SP contributes to cancer development in ways beyond UPR signaling.
Purpose of the Study:
- To define the concept of "tumor cell secretory addiction" from multiple perspectives.
- To explore the molecular, cellular, and therapeutic implications of this addiction.
- To discuss the role of UPR modulations in the context of secretory addiction.
Main Methods:
- Conceptual framework development.
- Literature review and synthesis.
- Analysis of molecular and cellular mechanisms.
Main Results:
- Established the concept of "tumor cell secretory addiction."
- Identified the SP as a multifaceted therapeutic target in oncology.
- Highlighted the interplay between UPR and secretory addiction in cancer.
Conclusions:
- The SP, beyond UPR, represents a critical vulnerability in cancer.
- "Tumor cell secretory addiction" offers a novel paradigm for cancer therapy.
- Modulating UPR is relevant but not the sole strategy for targeting secretory addiction.
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