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Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
Published on: August 25, 2023
A non-binary biopharmaceutical classification of drugs: the ABΓ system
Panos Macheras1, Vangelis Karalis1
1Laboratory of Biopharmaceutics - Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
The purpose of the present work is to develop a non-binary biopharmaceutical classification system the so called ABΓ system. The original mathematical model used for the development of BCS, appropriately modified, was applied to estimate the limiting values of drug solubility and permeability when the fraction of dose absorbed, Fa, was 0.90 or 0.20. The ABΓ system is based on the fraction of dose absorbed and relies on permeability, solubility plane. The first category (A, alpha) includes drugs with Fa ≥ 0.90, whereas the B (beta) category consists of drugs with Fa ≤ 0.20. The area lying between the two boundaries of A and B defines the third category (gamma), Γ, (0.20
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