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Updated: May 3, 2026
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
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[Neonatal renal candidiasis: a case report].
S Ben Ameur1, Y Hentati2, M Ben Dhaoui3
1Service de pédiatrie générale, CHU Hédi Chaker, route El Ain Km 0,5, 3029 Sfax, Tunisie; Faculté de médecine de Sfax, Sfax, Tunisie.
Summary
Neonatal renal candidiasis, a fungal infection in newborns, is increasingly diagnosed, particularly in premature infants. This case highlights a rare instance in a term infant, emphasizing the need for early diagnosis and treatment.
Area of Science:
- Neonatology
- Pediatric Infectious Diseases
- Mycology
Background:
- Neonatal renal candidiasis is an emerging concern, primarily affecting premature infants in neonatal intensive care units.
- Term infants with urogenital tract anomalies are also at risk.
- Early diagnosis and management are crucial for favorable outcomes.
Observation:
- A term infant born at 30 weeks' gestation developed sepsis due to Klebsiella pneumoniae.
- The infant presented with hypothermia and abdominal distention, with renal ultrasonography suggesting fungal disease.
- Blood, urine, and cerebrospinal fluid cultures were negative for fungi, but galactomannan antigen levels were elevated.
Findings:
- The infant was diagnosed with neonatal renal candidiasis.
- Treatment with intravenous Amphotericin B for 6 weeks was successful.
- End-organ evaluation ruled out disseminated fungal infection.
Implications:
- This case underscores the importance of considering fungal infections, specifically neonatal renal candidiasis, even in term infants with atypical presentations.
- Elevated galactomannan antigen levels can be a valuable diagnostic marker when cultures are negative.
- Prompt antifungal treatment leads to positive outcomes, preventing disseminated disease.
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