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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
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Topography-based keratoconus progression after corneal collagen crosslinking.
George D Kymionis1, Alexandra E Karavitaki, Michael A Grentzelos
1*Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Greece; and †Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.
Cornea
|January 25, 2014
Summary
Corneal collagen crosslinking (CXL) can prevent keratoconus progression. However, some patients may experience late-onset topographic progression years after CXL treatment.
Area of Science:
- Ophthalmology
- Corneal ectasias
- Refractive surgery
Background:
- Corneal collagen crosslinking (CXL) is a standard treatment for progressive keratoconus.
- It aims to halt or slow the worsening of the condition by strengthening corneal tissue.
Observation:
- This case report details two patients who underwent CXL for keratoconus.
- Both patients initially showed stability post-treatment.
Findings:
- Topographic examinations at 4 and 5 years post-CXL revealed increased keratometric values.
- This indicates a progression of keratoconus despite previous treatment and long-term stability.
Implications:
- Late-onset topographic progression can occur years after CXL.
- Long-term monitoring is crucial for patients treated with CXL for keratoconus.

