Related Experiment Video

Updated: May 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

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New trends in polymyxin B hemoperfusion: from 2006 to 2013

Dinna N Cruz1

  • 1Division of Nephrology-Hypertension, University of California, San Diego, Calif., USA.

Blood Purification
|January 25, 2014
PubMed

Insights

Polymyxin B (PMX) hemoperfusion effectively removes endotoxin, improving sepsis patient outcomes like blood pressure and mortality. Newer studies explore PMX for lung conditions and extended treatment durations.

Area of Science:

  • Microbiology
  • Critical Care Medicine
  • Biomaterials

Background:

  • Endotoxin from Gram-negative bacteria is crucial in sepsis pathogenesis.
  • Polymyxin B (PMX) hemoperfusion is an extracorporeal method for endotoxin removal.
  • Previous meta-analysis (1998-2006) showed PMX improved hemodynamic and respiratory parameters and reduced mortality in sepsis.

Purpose of the Study:

  • To review and synthesize recent clinical data on Polymyxin B (PMX) hemoperfusion.
  • To identify emerging applications and trends in PMX therapy.
  • To highlight areas for future research in endotoxin removal.

Main Methods:

  • Review of over 50 studies published since the 2006 meta-analysis.
  • Analysis of observational data focusing on clinical outcomes.
  • Examination of new therapeutic indications and treatment strategies for PMX.

Main Results:

  • PMX hemoperfusion demonstrated benefits in blood pressure, dopamine requirements, oxygenation, and mortality in earlier studies.
  • Recent observational studies indicate growing interest in PMX for interstitial pneumonias and idiopathic pulmonary fibrosis.
  • Trends suggest longer treatment durations and earlier initiation of PMX therapy.

Conclusions:

  • Polymyxin B hemoperfusion remains a relevant therapy for endotoxin removal in sepsis.
  • Emerging data suggests potential benefits in non-sepsis related pulmonary conditions.
  • Further rigorous studies are needed to validate newer applications and optimize PMX treatment protocols.

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