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Related Experiment Video

Updated: May 3, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Silicones as nonocclusive topical agents.

K De Paepe1, A Sieg, M Le Meur

  • 1Department of Toxicology, Dermato-Cosmetology and Pharmacognosy, Vrije Universiteit Brussel, Brussels, Belgium.

Skin Pharmacology and Physiology
|January 25, 2014
PubMed
Summary
This summary is machine-generated.

Common silicone excipients do not significantly reduce transepidermal water loss (TEWL) compared to controls, unlike petrolatum. While silicones do not moisturize skin, water-in-oil-plus-silicone creams do, without affecting TEWL.

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Materials Science

Background:

  • Silicone excipients offer emollient, skin-conditioning, and film-forming properties.
  • A misconception exists that silicones are occlusive, blocking water loss, contrary to their use in scar treatments.
  • This study investigates the occlusive properties of common silicone excipients versus petrolatum.

Purpose of the Study:

  • To clarify the occlusive nature of silicone excipients in topical formulations.
  • To compare the effects of silicones and petrolatum on skin barrier function.
  • To evaluate the moisturizing potential of silicone-containing creams.

Main Methods:

  • Investigated three common silicone excipients and three water-in-(oil-plus-silicone) creams (10% w/w silicone).
  • Measured transepidermal water loss (TEWL) and skin hydration after single topical application.
  • Utilized forearm skin of 26 healthy young female volunteers for testing.

Main Results:

  • Petrolatum and silicones reduced TEWL initially, but silicone's effect was not significantly different from the control.
  • Silicones did not demonstrate significant skin moisturizing effects.
  • Petrolatum created an occlusive layer, increasing skin hydration for over 4 hours.
  • Water-in-oil-plus-silicone creams moisturized skin without impacting TEWL.

Conclusions:

  • A distinct difference exists in the skin occlusive properties between petrolatum and common silicone excipients.
  • Silicone excipients are permeable to water vapor, unlike the occlusive nature of petrolatum.
  • Formulations with silicone excipients can provide moisturization without compromising the skin's natural water loss balance.