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Updated: May 3, 2026

A Method to Study de novo Formation of Chromatin Domains
Published on: August 23, 2019
The central role of EED in the orchestration of polycomb group complexes
Qi Cao1, Xiaoju Wang2, Meng Zhao3
11] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, Texas 77030, USA [4] Cancer Center, Houston Methodist Research Institute, Houston, Texas 77030, USA.
Abstract:
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.
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