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Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

587
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
587
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

143
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
143
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

337
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
337
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

671
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
671
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

408
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
408

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Related Experiment Video

Updated: May 3, 2026

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
03:37

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

Published on: June 6, 2025

645

Dental composite materials and renal function in children.

F L Trachtenberg1, P Shrader1, L Barregard2

  • 1New England Research Institutes, Watertown, Massachusetts, USA.

British Dental Journal
|January 25, 2014
PubMed
Summary

This study found no harmful associations between dental composite materials and children's renal function. Concerns about kidney health should not influence the choice of dental restoration materials or sealants.

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Area of Science:

  • Pediatric Dentistry
  • Nephrology
  • Environmental Health

Background:

  • Dental restorations, particularly resin-based composites, may release bisphenol A (BPA) intra-orally.
  • Potential systemic effects of BPA exposure from dental materials in children warrant investigation.

Purpose of the Study:

  • To assess the association between exposure to resin-based dental composites and renal function outcomes in children.
  • To determine if BPA release from dental materials impacts kidney health in pediatric populations.

Main Methods:

  • Prospective multi-center study involving 534 children aged 6-10 years.
  • Participants received either amalgam or resin-based composite restorations over a 5-year follow-up.
  • Renal function assessed via urinary biomarkers: albumin, gamma-glutamyl transpeptidase (GGT), and N-acetyl-β-D-glucosaminidase (NAG).

Main Results:

  • No association was found between exposure to dental composites (including sealants and restorations) and renal function levels.
  • Logistic regression models showed no link between composite materials and indicators of renal damage.
  • Analysis of covariance confirmed no significant relationship between composite exposure and kidney function markers.

Conclusions:

  • Dental composite materials are not associated with adverse renal function outcomes in children.
  • Concerns regarding renal function should not influence the selection of dental restoration materials or preventative sealants.
  • This research provides evidence supporting the safety of resin-based dental materials concerning pediatric kidney health.