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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Erythropoiesis01:14

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Related Experiment Video

Updated: May 3, 2026

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
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Long noncoding RNAs in erythropoiesis.

Patrick G Gallagher1

  • 1YALE UNIVERSITY SCHOOL OF MEDICINE.

Blood
|January 25, 2014
PubMed
Summary

Long noncoding RNAs (lncRNAs) are key regulators of gene expression. This study reveals new insights into the crucial roles of lncRNAs in red blood cell development (erythropoiesis).

Area of Science:

  • Molecular Biology
  • Genomics
  • Hematology

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized as critical regulators of gene expression.
  • Their specific roles in cellular differentiation, including erythropoiesis, are still being elucidated.

Purpose of the Study:

  • To investigate the function of lncRNAs in the process of erythropoiesis.
  • To provide novel insights into the regulatory mechanisms of lncRNAs during red blood cell development.

Main Methods:

  • Utilized a combination of genomics technology.
  • Employed bioinformatics analyses.
  • Conducted functional assays to determine lncRNA roles.

Main Results:

  • Identified specific lncRNAs involved in erythropoiesis.

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  • Characterized the regulatory functions of these lncRNAs.
  • Provided new understanding of lncRNA involvement in normal and abnormal erythropoiesis.

    • Conclusions:

    • lncRNAs play significant multifunctional roles in erythropoiesis.
    • This research represents a foundational step in understanding lncRNA regulation in red blood cell development.