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Related Experiment Video

Updated: Feb 21, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

Multiple interferon subtypes: the phenomenon and its relevance.

¹Department of Virology, Weizmann Institute of Science, Rehovot, Israel.

Journal of Interferon Research

|October 1, 1987

Summary

This summary is machine-generated.

Human interferon-alpha (IFN-alpha) and interferon-gamma (IFN-gamma) structures were determined using protein chemistry and molecular biology. This review discusses subtype significance and current findings in interferon research.

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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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Published on: June 14, 2018

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Published on: January 24, 2016

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Area of Science:

Biochemistry
Molecular Biology
Immunology

Background:

Human interferons (IFNs) are crucial cytokines involved in immune responses.
Understanding interferon structure is key to deciphering their diverse functions.
Numerous subtypes of IFN-alpha and IFN-gamma exist, necessitating detailed structural analysis.

Purpose of the Study:

To review key studies elucidating the structure of human interferon-alpha (IFN-alpha) and interferon-gamma (IFN-gamma) subtypes.
To discuss the functional significance of the multiplicity of IFN-alpha and IFN-gamma subtypes.
To integrate current research findings with structural insights.

Main Methods:

Combines protein chemistry techniques for structural determination.
Utilizes molecular biology approaches for genetic and functional analysis.
Reviews and synthesizes data from key published studies.

Main Results:

Elucidation of the detailed structures of various human IFN-alpha and IFN-gamma subtypes over the past decade.
Identification of structural features that may explain the multiplicity and distinct roles of different subtypes.
Correlation of structural data with emerging functional and biological results.

Conclusions:

The structural understanding of IFN-alpha and IFN-gamma subtypes has significantly advanced.
The multiplicity of subtypes is likely critical for fine-tuning immune responses.
Further research integrating structure-function relationships will enhance therapeutic applications of interferons.