Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches
Masakazu Ishii1, Hirotaka Katoh2, Tomomi Onaya1
1Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy, Tokyo 142-8555, Japan.
Purpose:
We investigated whether tryptophan hydroxylase 2 (TPH2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication.
Methods:
Forty-seven migraine patients (6 males and 41 females; 36.4 10.3 years) and 22 MOH patients (1 male and 21 females; 39.6 9.9 years) who had migraines participated in this study. The genotypes for the TPH2 gene polymorphisms (rs4565946, rs4570625, and rs4341581) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.
Results:
The rs4565946, rs4570625, and rs4341581 genotypes were similarly distributed between migraine patients and MOH patients.
Conclusion:
The results of this study showed no association between tryptophan TPH2 gene polymorphisms and the complication of MOH in patients with migraines.
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