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Related Experiment Video

Updated: May 3, 2026

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Cycloserine induced mania.

Ajay Kumar Bakhla¹, Prakash S Gore², Sanjay Lal Srivastava³

¹Department of Psychiatry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Industrial Psychiatry Journal

|January 25, 2014

Summary

A young man experienced manic symptoms after starting second-line tuberculosis treatment. Researchers identified cycloserine as the likely cause, exploring its neurobiological effects and implications for managing this adverse drug reaction.

Keywords:

Cycloserine mania psychosis

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Area of Science:

Neuropsychiatry
Pharmacology
Infectious Diseases

Background:

Multidrug-resistant tuberculosis (MDR-TB) requires complex, second-line treatments.
Adverse drug reactions can complicate treatment regimens for infectious diseases.

Observation:

A 21-year-old male patient developed acute manic symptoms.
The onset of manic symptoms coincided with the initiation of second-line anti-tuberculosis therapy.

Findings:

Cycloserine, a second-line anti-tuberculosis drug, was identified as the probable causative agent for the manic episode.
Neurobiological mechanisms underlying cycloserine-induced mania are discussed.

Implications:

Clinicians should monitor for psychiatric adverse effects during cycloserine treatment for MDR-TB.
Understanding the neurobiological basis of drug-induced mania is crucial for patient management and safety.