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Isolated Chorea Associated with LGI1 Antibody
Ritesh A Ramdhani1, Steven J Frucht1
1Movement Disorders Division, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Background:
Leucine-rich glioma inactivated 1 (LGI1) antibody produces a syndrome of limbic encephalitis, hyponatremia, and facio-brachial dystonic seizures that is non-paraneoplastic and responsive to corticosteroids. Parkinsonism, tremor, and generalized chorea are rare manifestations of LGI1, but, when present, commonly accompany other signs of limbic encephalitis.
Case Report:
We present a case of LGI1-related isolated chorea in a 53-year-old Japanese male. His chorea responded to high-dose steroids, suggesting a potential role for this synaptic antibody in triggering chorea.
Discussion:
This case highlights a new treatable etiology of chorea.
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