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Updated: May 3, 2026

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
Published on: December 28, 2021
Improvement in erectile function following weight loss in obese men: the SHED-IT randomized controlled trial
Abstract:
In a randomized controlled trial 145 sexually active overweight/obese men received either a male only SHED-IT (Self Help Exercise and Diet Using IT) weight loss program or a wait-list control. Erectile function (IIEF-5) was compared between men in the active intervention versus controls. IIEF-5 was assessed at baseline, 3 months (post-intervention) and 6 months (3-month follow-up). Intention-to-treat analysis revealed a significant intervention effect for erectile function (p = 0.018) at 6 months (+1.4; 95% CI 0.3,2.4; d = 0.32). A minimal contact, gender-tailored weight loss program significantly improved men's erectile function. Further studies evaluating change in erectile function with weight loss are warranted.
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