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Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

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Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery

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Published on: April 14, 2026

A multifunctional bilayered microstent as glaucoma drainage device.

Christian Wischke, Axel T Neffe, Bui Duc Hanh

Journal of Controlled Release : Official Journal of the Controlled Release Society

|January 25, 2014

Summary

This summary is machine-generated.

Researchers developed a novel polymeric microstent for glaucoma drainage, overcoming implant failures. This biodegradable device offers controlled drug release and shows promise for long-term efficacy.

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Area of Science:

Biomaterials Science
Ophthalmology
Polymer Engineering

Background:

Current glaucoma implants face issues like hypotony and fibrosis.
Need for advanced microstent technology for suprachoroidal drainage.

Purpose of the Study:

Design and fabricate multifunctional polymeric microstents for glaucoma.
Investigate drug release kinetics and material properties.
Assess translational aspects for clinical application.

Main Methods:

Solvent-free hot melt extrusion of poly(caprolactone) blends.
Fabrication of bilayered microstents with tailorable diameters (50-300 μm).
Diclofenac sodium used as a model drug for release studies.

Main Results:

Successful fabrication of microstents with controlled internal diameters.
Demonstrated spatially directed drug release with a drug-free PCL layer.
Slow degradation pattern (>1 year) and no adverse effects from drug loading (1-5 wt.%).

Conclusions:

Polymeric microstents offer a promising alternative to current glaucoma implants.
The developed microstents support controlled drug delivery and long-term function.
Further in vivo studies are warranted to evaluate long-term performance and capsule formation suppression.