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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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Chemical penetration enhancers.

Stephen J Newton1

  • 1Research & Development Department, EliteRx, Birmingham, Alabama, 35209, USA. stephen.newton@eliterx.net

International Journal of Pharmaceutical Compounding
|January 28, 2014
PubMed
Summary
This summary is machine-generated.

Chemical penetration enhancers improve drug absorption through the skin for transdermal delivery. This review details enhancer selection, mechanisms, common types, and alternatives for topical drug delivery.

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Area of Science:

  • Pharmacology
  • Dermatology
  • Drug Delivery Systems

Background:

  • Chemical penetration enhancers are key components in topical formulations.
  • They facilitate drug permeation across the skin barrier.
  • Transdermal drug delivery offers advantages over oral administration, including avoiding first-pass metabolism.

Purpose of the Study:

  • To review the selection criteria for chemical penetration enhancers.
  • To elucidate the mechanisms of action of various enhancers.
  • To discuss common enhancers, their classes, and alternative strategies.

Main Methods:

  • Literature review of chemical penetration enhancers.
  • Analysis of enhancer mechanisms.
  • Categorization of common enhancers and alternatives.

Main Results:

  • Detailed discussion on the selection and classification of enhancers.
  • Explanation of how enhancers increase drug permeability.
  • Identification of prevalent chemical penetration enhancers and their applications.

Conclusions:

  • Chemical penetration enhancers are vital for effective transdermal drug delivery.
  • Understanding enhancer mechanisms and types is crucial for formulation development.
  • Alternatives exist, offering flexibility in topical preparation design.