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Renal tubular function in normal pregnancy.

A M Kelly, M B McNay, H P McEwan

    British Journal of Obstetrics and Gynaecology
    |March 1, 1978
    PubMed
    Summary
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    Beta2-microglobulin and gamma-glutamyl transpeptidase levels in maternal blood and urine are stable during normal pregnancy. These biomarkers can effectively assess kidney tubular function in pregnant individuals with renal disorders.

    Area of Science:

    • Clinical Chemistry
    • Renal Physiology
    • Maternal-Fetal Medicine

    Background:

    • Kidney function assessment is crucial in pregnancy, especially with renal complications.
    • Biomarkers for evaluating renal tubular function in pregnant individuals are needed.

    Purpose of the Study:

    • To determine the serial changes in maternal plasma and urine concentrations of beta2-microglobulin and gamma-glutamyl transpeptidase during normal pregnancy.
    • To evaluate the utility of these markers for assessing renal tubular function in pregnancies affected by renal disorders.

    Main Methods:

    • Serial measurement of maternal plasma and urine beta2-microglobulin.
    • Serial measurement of maternal plasma and urine gamma-glutamyl transpeptidase (EC:2.3.2.2).
    • Analysis of marker concentrations throughout normal pregnancy.

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    Main Results:

    • Maternal plasma and urine concentrations of beta2-microglobulin remained constant throughout normal pregnancy.
    • Maternal plasma and urine concentrations of gamma-glutamyl transpeptidase remained constant throughout normal pregnancy.

    Conclusions:

    • Beta2-microglobulin and gamma-glutamyl transpeptidase are stable biomarkers during normal pregnancy.
    • These stable parameters can be reliably used to evaluate renal tubular function in pregnancies with renal disorders.