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Published on: April 20, 2018
Effects of resveratrol and irradiation upon oral squamous cell carcinoma cells
Antonio Navarro Atienzar1, Fabio Camacho-Alonso, Pia Lopez-Jornet
1Department of Oral Medicine, Faculty Medicine and Dentistry University of Murcia , Murcia , Spain.
Objective:
To evaluate the effects of resveratrol and irradiation on oral squamous cell carcinoma (OSCC).
Materials And Methods:
Resveratrol was administered at doses of 5, 10, 25, 50 and 100 µM to PE/CA-PJ15 (OSCC) cultures irradiated with different doses (1, 2.5 and 5 Gy). Effects upon cell viability, apoptosis and migration were evaluated after 24, 48 and 72 h incubation.
Results:
After 72 h of incubation, the 100 µM dose of resveratrol induced the greatest decrease in cell viability at all irradiation doses. After 24, 48 and 72 h of incubation, 100 µM of resveratrol induced the greatest cell apoptosis at all irradiation doses. The greatest alterations in the distribution of the G0-G1, G2-M and S phases of the cell cycle were recorded with 50 and 100 µM of resveratrol; after 24, 48 and 72 h of incubation, both these doses resulted in an increase in the S phase, at the expense of the G0-G1 and G2-M phases.
Conclusions:
Resveratrol increases cytotoxic activity in the PE/CA-PJ15 cell line and reduces cell migration capacity, while the combination of resveratrol and irradiation exerts a synergic effect.
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