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Phase behavior and relative stability of malonamide polymorphs.

Yohann Corvis1, Nicolas Guiblin, Philippe Espeau

  • 1EA 4066 "Physico-Chimie Industrielle du Médicament", Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes , 4 Avenue de l'Observatoire, 75 006 Paris, France.

The Journal of Physical Chemistry. B
|January 28, 2014
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Summary

This study characterizes malonamide polymorphs using thermal analysis and X-ray diffraction. Researchers determined the thermodynamic stability and phase transitions between monoclinic, orthorhombic, and quadratic forms.

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Area of Science:

  • Solid-state chemistry
  • Materials science
  • Crystallography

Background:

  • Malonamide exists in three known solid forms (polymorphs).
  • Understanding polymorph behavior is crucial for material properties and applications.
  • Thermodynamic relationships between polymorphs dictate their stability and interconversion.

Purpose of the Study:

  • To characterize the three known polymorphs of malonamide.
  • To determine the melting thermodynamic characteristics of each malonamide form.
  • To establish the relative thermodynamic stability and phase behavior among the polymorphs.

Main Methods:

  • Thermal analysis (e.g., Differential Scanning Calorimetry, Thermogravimetric Analysis).
  • X-ray powder diffraction (XRPD) for structural characterization.
  • Thermodynamic modeling based on experimental data.

Main Results:

  • Melting thermodynamic characteristics for the three malonamide polymorphs were determined.
  • An enantiotropic relationship was identified between the monoclinic and orthorhombic phases.
  • The quadratic phase was found to be monotropic relative to the other two forms.

Conclusions:

  • The study elucidates the thermodynamic stability and phase transitions of malonamide polymorphs.
  • This provides critical data for controlling malonamide's solid form in various applications.
  • The findings contribute to the broader understanding of polymorphism in organic materials.