Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
Micelles01:30

Micelles

364
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
364
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.3K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.3K
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

406
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
406
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

3.1K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modular Synthesis of Dendritic Oligo-Glycerol Cationic Surfactants for Enhanced Antibacterial Efficacy.

Angewandte Chemie (International ed. in English)·2025
Same author

Three-Dimensional Polyglycerol-PEG-Based Hydrogels as a Universal High-Sensitivity Platform for SPR Analysis.

Analytical chemistry·2025
Same author

Chemical linkers switch triglycerol detergents from bacterial protein purification to mild antibiotic amplification.

Communications chemistry·2025
Same author

Photo-regulated disulfide crosslinking: a versatile approach to construct mucus-inspired hydrogels.

Chemical science·2025
Same author

Mussel-inspired cross-linking mechanisms enhance gelation and adhesion of multifunctional mucin-derived hydrogels.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Measuring the Thermal Unfolding of Lysozyme: A Critical Comparison of Differential Scanning Fluorimetry and Differential Scanning Calorimetry.

ChemistryOpen·2025

Related Experiment Video

Updated: May 3, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

10.2K

Nanodynamics of dendritic core-multishell nanocarriers.

Alexander Boreham1, Marcus Pfaff, Emanuel Fleige

  • 1Institut für Experimentalphysik, Freie Universität Berlin , Arnimallee 14, 14195 Berlin, Germany.

Langmuir : the ACS Journal of Surfaces and Colloids
|January 28, 2014
PubMed
Summary

Polyglycerol-based core-multishell nanotransporters show temperature-dependent flexibility, enhancing drug mimetic mobility above 31°C. These nanocarriers retain cargo during heating and dilution, crucial for nanomedicine applications.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

8.3K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.8K

Related Experiment Videos

Last Updated: May 3, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

10.2K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

8.3K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.8K

Area of Science:

  • Polymer Science
  • Nanomedicine
  • Physical Chemistry

Background:

  • Polymeric nanocarrier molecular dynamics influence cargo interaction and delivery.
  • Tailoring dendritic architecture is key for nanomedicine, drug, dye, and gene delivery.

Purpose of the Study:

  • Investigate polyglycerol-based core-multishell (CMS) nanotransporters' dynamics.
  • Understand the interplay of polymer dynamics, temperature, and cargo interactions.
  • Assess cargo retention and temperature responsiveness for biomedical applications.

Main Methods:

  • Time-resolved fluorescence depolarization to study rotational diffusion.
  • UV/vis and fluorescence lifetime measurements for dye environment analysis.
  • Investigation of CMS nanotransporters with Nile Red and Indocarbocyanine.

Main Results:

  • Nile Red distribution within nanotransporter shells is solvent and temperature-dependent.
  • Polymer branch flexibility transitions at temperatures above 31°C, increasing Nile Red mobility.
  • No cargo loss observed upon dilution or heating, indicating stable cargo retention.

Conclusions:

  • Polyglycerol-based CMS nanotransporters exhibit temperature-responsive behavior.
  • The nanocarriers effectively retain cargo, fulfilling requirements for drug delivery.
  • These findings offer insights for designing tailored nanocarriers for nanomedicine.