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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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Controlled release of protein from biodegradable multi-sensitive injectable poly(ether-urethane) hydrogel.

Xiaomeng Li1, Yangyun Wang, Jiaming Chen

  • 1Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.

ACS Applied Materials & Interfaces
|January 28, 2014
PubMed
Summary

New biodegradable polymers form injectable hydrogels that respond to temperature and pH. These multi-sensitive hydrogels enable controlled release of protein drugs like insulin for targeted delivery applications.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Injectable hydrogels offer advantages for minimally invasive drug delivery.
  • Developing smart polymers that respond to physiological conditions is crucial for controlled release.

Purpose of the Study:

  • To synthesize and characterize biodegradable multi-sensitive polymers for injectable hydrogel applications.
  • To evaluate the potential of these hydrogels for controlled protein and drug delivery.

Main Methods:

  • One-pot condensation synthesis of poly(ether-urethane)s using poly(ethylene glycol), 2,2'-dithiodiethanol, N-methyldiethanolamine, and hexamethylene diisocyanate.
  • Investigation of sol-gel phase transition behavior in response to temperature and pH.
  • In vitro evaluation of insulin release from hydrogel formulations.

Main Results:

  • Synthesized biodegradable multi-sensitive poly(ether-urethane)s exhibited sol-to-gel phase transitions with increasing temperature and pH.
  • The hydrogels demonstrated in situ gelation under physiological conditions (37 °C, pH 7.4).
  • Controlled release of insulin was achieved, modulated by the 2,2'-dithiodiethanol content, indicating tunable degradation.

Conclusions:

  • The developed multi-sensitive polymers are suitable for creating injectable hydrogels for controlled protein/drug delivery.
  • These materials show promise as advanced drug delivery systems with tunable release profiles.
  • The multi-responsive nature of these hydrogels facilitates site-specific and controllable delivery in vivo.