Multifunctional two-photon active silica-coated Au@MnO Janus particles for selective dual functionalization and...

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Janus nanoparticles offer unique properties for advanced applications.
• Developing multifunctional nanoparticles for theranostics is crucial for personalized medicine.

Purpose of the Study:

• To synthesize monodisperse, multifunctional, and nontoxic Au@MnO Janus nanoparticles.
• To enable surface functionalization and dye labeling for theranostic applications.
• To investigate the potential of these nanoparticles for biomedical applications.

Main Methods:

• Seed-mediated nucleation and growth technique for precise control over particle synthesis.
• Selective silica coating of the metal oxide domain for biomolecule conjugation.
• Characterization using HR-TEM, PXRD, UV-vis, CLSM, and DLS.
• Biocompatibility assessment via cell viability assays.

Main Results:

• Successfully synthesized Au@MnO Janus nanoparticles with controlled sizes and morphologies.
• Achieved selective silica coating, enabling efficient biomolecule conjugation.
• Demonstrated nanoparticle stability in buffer and serum without aggregation.
• Confirmed biocompatibility with Caki 1 and HeLa cells.
• Observed high two-photon activity and no electronic interaction between dye and gold domains.

Conclusions:

• The synthesized Au@MnO@SiO2 Janus nanoparticles are promising for theranostic applications.
• Their controlled synthesis, stability, and biocompatibility make them suitable for drug delivery and imaging.
• Further research can explore their specific therapeutic and diagnostic capabilities.