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ATF3 activates Stat3 phosphorylation through inhibition of p53 expression in skin cancer cells

Zhen-Feng Hao1, Jun-Hong Ao, Jie Zhang

  • 1Graduate Management Brigade, Third Military Medical University, Chongqing, China

Asian Pacific Journal of Cancer Prevention : APJCP
|January 28, 2014
PubMed
Abstract

Insights

Activating transcription factor 3 (ATF3) promotes skin cancer cell proliferation by inhibiting p53 and activating Stat3. This transcription factor may enhance keratinocyte tumor development, highlighting its role in skin cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Activating transcription factor 3 (ATF3) is a transcription factor implicated in keratinocyte tumor formation.
  • The specific role and mechanisms of ATF3 in human skin cancer are not fully understood.

Purpose of the Study:

  • To investigate the role of ATF3 in human skin cancer.
  • To elucidate the molecular mechanisms by which ATF3 influences skin cancer cell proliferation and tumor development.

Main Methods:

  • Clinical analysis of skin cancer tissues from 30 patients and 30 normal donors.
  • Functional assays to assess the impact of ATF3 on skin cancer cell proliferation.
  • Investigation of ATF3's effect on p53 expression and Stat3 phosphorylation.

Main Results:

  • ATF3 was found to be accumulated in skin cancer tissues.
  • ATF3 significantly promoted skin cancer cell proliferation.
  • ATF3 activated Stat3 phosphorylation by regulating p53 expression, a process crucial for proliferation.

Conclusions:

  • ATF3 promotes skin cancer cell proliferation and keratinocyte tumor development.
  • The mechanism involves ATF3 inhibiting p53 expression, subsequently activating the Stat3 signaling pathway.

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