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Nitroglycerin-sensitive and -resistant contractions mediated by receptor-operated calcium channels in rabbit ear
Y Akimoto1, K Kurahashi, H Usui
1Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
Japanese Journal of Pharmacology
|August 1, 1987
Abstract:
In isolated rabbit ear arteries incubated in a Ca2+-free medium with EGTA and nifedipine in the presence of norepinephrine, serotonin or histamine, an addition of Ca2+ induced a tonic contraction which is due to Ca2+ entry through receptor-operated Ca2+ channels (ROCs). Nitroglycerin (10(-4) M) significantly inhibited the ROCs-dependent contractions produced by serotonin or histamine, but failed to inhibit the ROCs-dependent contraction by norepinephrine. These results suggest the possible existence of two types of receptor-operated Ca2+ channels in rabbit ear artery.