Related Experiment Video
Updated: May 3, 2026

Assessing Activity-based Anorexia in Mice
Published on: May 14, 2018
Brain structure alterations associated with weight changes in young females with anorexia nervosa: a case series
Tone Seim Fuglset1, Tor Endestad, Nils Inge Landrø
1a Oslo University Hospital , Oslo , Norway.
Abstract:
Structural brain changes associated with starvation and clinical measurements were explored in four females with anorexia nervosa with different clinical course, at baseline and 1-year follow-up, after receiving intensive inpatient treatment at a specialized eating disorder unit. Global volume alterations were associated with weight changes. Regional volume alterations were also associated with weight changes, with the largest changes occurring in the nucleus accumbens, amygdala, pallidum, and putamen. Largest changes in cortical thickness occurred in the frontal and temporal lobes. The results are preliminary; however, they show that fluctuations in weight are associated with brain volume alterations, especially gray matter. We suggest that these parts of the brain are vulnerable to starvation and malnutrition, and could be a part of the pathophysiology of AN.
Related Concept Videos
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Bulimia Nervosa
Binge Eating Disorders
Alzheimer Disease ll: Pathophysiology
Cellular Adaptation I: Introduction and Atrophy
Alzheimer Disease l: Introduction

