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Enlightened Mannhemia haemolytica lung inflammation in bovinized mice
Fabio Franco Stellari, Sophia Lavrentiadou, Francesca Ruscitti
1Department of Medical Veterinary Science, University of Parma, via del Taglio 10, 43126 Parma, Italy. gaetano.donofrio@unipr.it.
Veterinary Research
|January 28, 2014
Abstract:
Polymorphonuclear cells diapedesis has an important contribution to the induced Mannhemia haemolytica (M. haemolytica) infection lung inflammation and IL-8 is the primary polymorphonuclear chemoattractant. Using a bovine IL-8/luciferase transiently transgenized mouse model, the orchestration among M. haemolytica, IL-8 promoter activation and neutrophilia was followed in real time by in vivo image analysis.
