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Collateral arterial tree and responses to serotonin
1Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Journal of Cardiovascular Pharmacology
|January 1, 1987
Summary
Growing blood vessels are sensitive to serotonin, which can cause arterial spasms in advanced atherosclerosis. Ketanserin, a 5-HT2-receptor blocker, targets this receptor, offering new treatment options for arterial spasms.
Area of Science:
- Cardiovascular biology
- Pharmacology
Background:
- Collateral arteries exhibit heightened sensitivity to serotonin.
- Advanced atherosclerosis leads to platelet activation and serotonin release.
- Serotonin release can trigger collateral arterial spasm.
Purpose of the Study:
- To identify the specific serotonin receptor involved in collateral arterial spasm.
- To explore the therapeutic potential of targeting this receptor.
Main Methods:
- Investigated the role of serotonin in collateral arterial function.
- Utilized ketanserin, a selective 5-HT2-receptor antagonist.
Main Results:
- Demonstrated that collateral arteries are highly sensitive to serotonin.
- Confirmed that 5-HT2 receptors mediate serotonin-induced arterial spasm.
- Ketanserin effectively blocks this spasm.
Conclusions:
- The 5-HT2 receptor is critically involved in serotonin-mediated collateral arterial spasm.
- Ketanserin represents a promising therapeutic strategy for conditions involving arterial spasm due to atherosclerosis.