Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Diffusion in the Membrane

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics.

bioRxiv : the preprint server for biology·2026

Same author

Steady-state analysis of mean first-passage times with stochastic switching.

The Journal of chemical physics·2026

Same author

The multiple sclerosis drug fingolimod induces pore-like membrane defects, contributing to its antimicrobial activity.

The Journal of biological chemistry·2026

Same author

Multiple Sclerosis Drug Fingolimod Exhibits Antibacterial Activity through Bacterial Membrane Permeabilization.

bioRxiv : the preprint server for biology·2026

Same author

Logarithmic Binding and Stretched-Exponential Kinetics in Peripheral Protein Interactions with Lipid Membrane Surfaces.

The journal of physical chemistry letters·2026

Same author

Solute flux through a fluctuating membrane channel.

Physical chemistry chemical physics : PCCP·2026

Search research articles

Related Experiment Video

Updated: May 3, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Discriminating between anomalous diffusion and transient behavior in microheterogeneous environments.

Alexander M Berezhkovskii¹, Leonardo Dagdug², Sergey M Bezrukov³

¹Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Center for Information Technology, National Institutes of Health, Bethesda, Maryland; Mathematical and Statistical Computing Laboratory, Division for Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland.

Biophysical Journal

|January 28, 2014

Summary

This summary is machine-generated.

Effective free diffusion accurately describes media only at long times. Transient behaviors at intermediate times can mimic anomalous subdiffusion, but this study clarifies how to distinguish between them.

More Related Videos

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Published on: August 16, 2021

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

Related Experiment Videos

Last Updated: May 3, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Published on: August 16, 2021

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

Area of Science:

Physics
Physical Chemistry
Materials Science

Background:

Diffusion processes are fundamental in various scientific fields.
Understanding diffusion behavior in complex media is crucial.
Distinguishing true anomalous diffusion from transient effects is challenging.

Purpose of the Study:

To clarify the conditions under which diffusion can be described as effective free diffusion.
To differentiate transient diffusion behaviors from anomalous subdiffusion.
To provide guidelines for accurate interpretation of diffusion data.

Main Methods:

Analysis of mean-square displacement in macrohomogeneous and microheterogeneous media.
Theoretical examination of diffusion dynamics at different timescales.
Comparison of transient diffusion characteristics with anomalous subdiffusion models.

Main Results:

Effective free diffusion is only applicable at sufficiently long timescales.
Intermediate timescales exhibit transient behavior that can be mistaken for anomalous subdiffusion.
Clear criteria are established to discriminate between transient and anomalous diffusion.

Conclusions:

Transient diffusion effects in complex media are distinct from anomalous subdiffusion.
Accurate interpretation of diffusion requires consideration of timescales.
The findings aid in precise characterization of diffusion phenomena.