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Updated: May 3, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
Published on: May 31, 2018
[Macrophage activation syndrome: rare complication of murine typhus]
C Loussaief1, A Toumi1, H Ben Brahim1
1Service des maladies infectieuses, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie.
Introduction:
Typhi is one of the rickettsial species endemic in the Mediterranean countries and is associated with the zoonotic infection of murine typhus, which may have a complicated course especially in adult patients. The association with macrophage activation syndrome (MAS) has rarely been reported in the medical literature.
Case Report:
We describe a case of murine typhus in a diabetic woman complicated with MAS, who was effectively treated with cyclin and parenteral immunoglobulin.
Conclusion:
The murine typhus can be exceptionally complicated with SAM. This infection should be suspected in front of the discovery of SAM.

