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Control of gold nanoparticles based on circular DNA strand displacement
Cheng Zhang1, Jingjing Ma1, Jing Yang2
1Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, People's Republic of China.
Abstract:
In this study, DNA strand displacement is utilized to control the aggregation of DNA/gold nanoparticles (AuNPs) based on circular DNA, in which DNA/AuNP conjugates are captured and released by adding different DNA signal strands. Using this strategy, single DNA/nanoparticle building blocks are capable of assembling into complex structures of two and three circular DNA/nanoparticles. The existence of these structures is demonstrated by gel electrophoresis and transmission electron microscopy (TEM) analysis. This advance has potential applications in controlling, transporting and detecting DNA/AuNP conjugates with subsequent manipulation of the structure and function of these assemblies.
