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Electrocardiographic changes associated with insulin resistance.
M Granér1, M O Pentikäinen1, R Siren2
1Thorax-center, Division of Cardiology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|January 28, 2014
Summary
Metabolic syndrome (MetS) is linked to cardiac steatosis, which shows on electrocardiograms (ECG). Increased heart fat correlates with ECG changes like leftward QRS axis shift and lower voltage, potentially masking heart enlargement.
Area of Science:
- Cardiology
- Metabolic Diseases
- Medical Imaging
Background:
- Cardiac steatosis is associated with increased heart disease risk.
- The metabolic syndrome (MetS) encompasses multiple cardiovascular risk factors.
- Understanding the link between cardiac fat, ECG, and MetS is crucial for cardiovascular health.
Purpose of the Study:
- To investigate the association between cardiac steatosis, ECG abnormalities, and MetS components.
- To explore how myocardial triglyceride content relates to ECG parameters.
- To determine predictors of ECG changes in individuals with MetS.
Main Methods:
- Examined 12-lead ECG and laboratory data in men with and without MetS.
- Measured myocardial triglyceride (MTG) content using MR spectroscopy.
- Assessed epicardial and pericardial fat via MR imaging.
Main Results:
- Men with MetS had higher MTG content, epicardial, and pericardial fat.
- Increased heart rate, longer PR interval, leftward QRS axis shift, and lower QRS voltage were observed in MetS group.
- QRS axis and voltage correlated inversely with MTG content, waist circumference, BMI, TGs, and glucose.
Conclusions:
- MetS and cardiac steatosis are associated with multiple ECG changes.
- Leftward QRS axis shift and lower QRS voltage are characteristic of MetS.
- Standard ECG may underestimate left ventricular hypertrophy in obese individuals with cardiometabolic risk factors.
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